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Seth is
a Postdoctoral Research Fellow in the biomolecular
modelling Group in the Centre for Computational
Molecular Science.
Professional Qualifications:
• B.S.
Physics (Honors), College of William & Mary, 1997
• Ph.D. Centre for Biophysics & Computational
Biology, University of
Illinois at Urbana-Champaign, 2004
Research Projects:
Excited state quantum chemistry of
red
fluorescent protein chromophores,
Fragment Molecular orbital descriptions of red
fluorescent proteins
Awards:
Molecular Biophysics Training Grant Recipient, 1997
Selected Publications 2000-present:
1. C. Ko, B. Levine, A. Toniolo, L.
Manohar, S. Olsen, H.-J. Werner and
T.J. Martinez, 'Ab Initio Excited State Dynamics
of the Photoactive
Yellow Protein Chromophore', J. Amer. Chem.
Soc., 125 pp. 12710 (2003)
2. A. Toniolo, S. Olsen, L. Manohar
and T.J. Martinez, 'Conical
Intersection Dynamics in Solution: The Chromophore
of Green Fluorescent
Protein', Faraday Discussions, 127 pp.
149 (2004)
3. A. Toniolo, S. Olsen, L. Manohar
and T.J. Martinez, 'Ultrafast
Excited State Dynamics in Green Fluorescent Protein
Chromophore', in
Femtochemistry and Femtobiology: Ultrafast Events in
Molecular Science,
Ed. M. Martin and J.T. Hynes (Amsterdam,
Elsevier, 2004)
4. P.G. Wilman, J. Petersen, A.
Pettikiriarachchi, A.M. Buckle, S.C.
Smith, S. Olsen, M. Perugini, R.J. Devenish,
M. Prescott and J.
Rossjohn, 'The 2.1 A Crystal Structure of the
Far-Red fluorescent
protein HcRed: Inherent Conformational Flexibility
of the Chromophore', J. Molecular Bio.
349 pp. 223-237 (2005)
5. A. Toniolo, B. Levine, A. Thompson, J.
Quenneville, M. Ben-Nun, J.
Owens, S. Olsen, L. Manohar and T.J.
Martinez, 'Photochemistry from
First Principles and Direct Dynamics', in
Computational Methods in
Organic Photochemistry, Ed. A. Kutateladze
(New York, Marcel-Dekker, 2005)
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6. S. Olsen, A. Toniolo, C. Ko, L. Manohar,
K. Lamothe and T.J.
Martinez, 'Computation of Reaction Mechanisms and
Dynamics in
Photobiology' in Computational Photochemistry,
Ed. M. Olivucci
(Elsevier)
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7. P.G. Wilmann,
J. Battad, T. Beddoe, S. Olsen, S.C. Smith, S. Dove, R. Devenish, J.
Rossjohn and M. Prescott.
¡§The 2.1Å crystal structure of a
pocilloporin at pH 3.5: the structural basis for pH dependent colour
transitions and their linkages to the binding of halides¡¨.
Photochemistry and Photobiology,
82, 359-366 (2006)
8.
S.C. Olsen, M.
Prescott, P. Wilmann, J. Battad, J. Rossjohn and Sean C. Smith,
¡§Determination of Chromophore Charge States in the Low pH Color
Transition of the Fluorescent Protein Rtms5H146S via Time-Dependent DFT¡¨, Chem. Phys. Lett.,
420, 507-511 (2006).
9.
Seth Olsen and Sean C. Smith, ¡§Trans-Cis
Isomerism and Acylimine Formation in DsRed Chromophore Models:
Intrinsic Rotation Barriers¡¨, Chem. Phys. Lett., 426,
159-162 (2006)
10.
Seth Olsen and Sean C. Smith, ¡§The Radiationless Decay of Red
Fluorescent Protein Chromophore Models via Twisted Intramolecular
Charge Transfer States¡¨, J. Amer. Chem. Soc., accepted
(2006).
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Contact Details:
Dr. Seth Olsen
Biomolecular Modelling Group
Centre for Computational Molecular Science
Room 230, Australian Institute of Bioengineering and
Nanotechnology
Building #75
The University of Queensland
QLD 4072, Brisbane, Australia
Tel +61 (0)7 3346 3976
Fax +61 (0)7 3346 3992
email: s.olsen1@uq.edu.au
Web:
www.ccms.uq.edu.au
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